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ea0099p465 | Diabetes, Obesity, Metabolism and Nutrition | ECE2024

PDE4 inhibition attenuates non-alcoholic fatty liver disease by increasing vldl secretion in obese animals

da Silva Hellen , Amelia Montenegro Maria , Gebenlian Juliana , Antunes Rodrigues Jose , de Paula Francisco , Elias Lucila

Non-alcoholic fatty liver disease (NAFLD) is characterized by the pathological increase of lipid droplets, altered fat metabolism in hepatocytes and increased inflammation. Phosphodiesterase 4 (PDE4) modulates the inflammatory responses and its inhibitor can strongly reduce TNF-α release and inflammation. Additionally, PDE4 knockout mice were shown to be resistant to diet-induced obesity (DIO). The aim of this study was to investigate the role of pharmacological PDE4 inhi...

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ea0090p337 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

PDE4 Inhibitors Act in The Brain to Ameliorate Metabolic Parameters in Diet-Induced Obesity

da Silva Hellen , Mendonca Duarte Luiza , De Souza Seixas Michele , Antunes Rodrigues Jose , de Paula Francisco , Elias Lucila

Obesity is associated with peripheral and central low grade inflammation characterized by the increase in pro-inflammatory cytokines, such as tumor necrosis factor alpha (TNF). Phosphodiesterase 4 (PDE4) modulates the inflammatory responses and its inhibitor can strongly reduce TNF release and inflammation. Additionally, PDE4 knockout mice were shown to be resistant to diet-induced obesity (DIO). The aim of this study was to investigate the role of central and peripheral effec...

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Endocrine Abstracts

PDE4 inhibition attenuates non-alcoholic fatty liver disease by increasing vldl secretion in obese animals

PDE4 Inhibitors Act in The Brain to Ameliorate Metabolic Parameters in Diet-Induced Obesity

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